Onset of heart failure determines the hepatic cell death pattern

Onset of heart failure determines the hepatic cell death pattern.

BACKGROUND AND RATIONALE Acute and chronic heart failure (HF) may affect the liver, but the underlying mechanisms that lead to progressive liver damage are poorly understood. The hepatic cytokeratin-18 (CK18) epitopes M65 and M30 have been reported to distinguish between overall (necrotic) and apoptotic cell death, respectively. We aimed to evaluate the predominant hepatic cell death pattern in...

The role of cell death in heart failure.

In this issue of Circulation Research, Guerra and colleagues1 report that myocyte death in the failing human heart is gender dependent. This work is in continuation of Dr Anversa’s numerous reports on the occurrence of apoptosis, necrosis, and proliferation in the failing human heart, as well as under various experimental conditions including, among others, aging and myocardial infarction in ra...

Death begets failure in the heart.

Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

of the American Heart Association Heart Failure 1 Death in Heart Failure : a Community Perspective Danielle

Adiponectin resistance in heart failure and the emerging pattern of metabolic failure in chronic heart failure.

In recent years, an interesting shift in our understanding of chronic heart failure (CHF) pathophysiology may be observed. Beyond the traditional concepts of hemodynamic failure and neuroendocrine activation, it is increasingly appreciated that CHF is a much more complex and truly systemic disease including the peripheral organs and whole body regulatory processes as well. Novel concepts such a...